CPEB4 links the clock and the UPR to protect the liver

Nature Cell Biology 19, 79 (2017).
doi:10.1038/ncb3460

Authors: Paul C. Moore & Scott A. Oakes
Under misfolded protein stress, the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis, or commits the cell to apoptosis. A study now uncovers how the UPR is governed by the circadian clock to adjust ER protein-folding capacity to metabolic demand and protect against liver damage.

Source: Nature Cell Biology - January 30, 2017 Category: Cytology Authors: Paul C. Moore Scott A. Oakes Tags: News and Views Source Type: research