1,25-dihydroxyvitamin D3 prevents deleterious effects of homocysteine on mitochondrial function and redox status in heart slices

Since homocysteine (Hcy) is a risk factor for cardiovascular disease and vitamin D deficiency can contribute to cardiovascular pathologies, in the present study we tested the hypothesis that Hcy could impair energy metabolism, mitochondrial function and redox status in heart slices of Wistar rats and that 1,25-dihydroxivitamin D3 (calcitriol) treatment could prevent such effects. Heart slices were first pretreated with three different concentrations of calcitriol (50nM, 100nM and 250nM) for 30min at 37 °C, after which Hcy was added to promote deleterious effects on metabolism.

Source: Nutrition Research - January 28, 2017 Category: Nutrition Authors: Aline Longoni, Janaina Kolling, Cassiana Siebert, Jo ão Paulo dos Santos, Jussemara Souza da Silva, Letícia F. Pettenuzzo, Leo Anderson Meira-Martins, Carlos-Alberto Gonçalves, Adriano M de Assis, Angela TS Wyse Source Type: research