Ezogabine skin discoloration is reversible after discontinuation

We present a case of ezogabine-induced skin discoloration that resolved completely after discontinuation. A 55-year-old woman started ezogabine 400mg three times a day at age 41. Bluish pigmentation over the toe nails, finger nails, around eyes and over and around lips was first noted after 5years of treatment. Ezogabine was discontinued eight years after initiation. Skin discoloration improved within 6months and completely resolved within 6years of discontinuation. This case suggests that ezogabine-induced discoloration is reversible after discontinuation of treatment. Graphical abstract

Source: Epilepsy and Behavior Case Reports - January 28, 2017 Category: Neurology Source Type: research