Anticonvulsant effect of Sodium cyclamate and propylparaben on PTZ ‐induced seizures in zebrafish

This article is protected by copyright. All rights reserved. PTZ induced seizures in zebrafish, suggesting that can be used as a preclinical animal model to study seizure. Using this model, we demonstrate that sodium cyclamate (an artificial sweetener) and propylparaben (antimicrobial agent) modify the seizure threshold. In red: computer‐generated behavioral traces produced by pentylenetetrazole (PTZ), valproate (VPA), sodium cyclamate (SC) and propylparaben (PP) exposure in adult zebrafish tested in a 15 minutes observation tank.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fsyn.21961

Source: Synapse - January 24, 2017 Category: Neurology Authors: Antonella Pisera ‐Fuster, Sofía Otero, Alan Talevi, Luis Bruno‐Blanch, Ramón Bernabeu Tags: Research Article Source Type: research