Locus coeruleus at asymptomatic early and middle Braak stages of neurofibrillary tangle pathology

ConclusionsComplex alteration of several metabolic pathways occurs in the LC accompanying NFT formation at early and middle asymptomatic stages of NFT pathology. Dopaminergic/noradrenergic denervation and increased expression of α2A adrenergic receptor in the hippocampus and amygdala occur at first stages of NFT pathology, suggesting compensatory activation in the face of decreased adrenergic input occurring before clinical evidence of cognitive impairment and depression.This article is protected by copyright. All rights reserved.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fnan.12386

Source: Neuropathology and Applied Neurobiology - November 30, 2016 Category: Neurology Authors: Pol Andr és‐Benito, Victor Fernández‐Dueñas, Margarita Carmona, Luis Alberto Escobar, Benjamín Torrejón‐Escribano, Ester Aso, Francisco Ciruela, Isidro Ferrer Tags: Original Article Source Type: research