A Rare Breed: Wild-Type BRAF and IgHV Expression in a 29 Year Old Lady with Classical Hairy Cell Leukemia

Publication date: Available online 24 January 2017 Source:Leukemia Research Reports Author(s): Aneesha Hossain, Hind Rafei, Amar Jariwala, Khaled El-Shami The V600 BRAF mutation has been described as a key mutation in the pathogenesis of classical hairy cell leukemia (c-HCL) cases without expression of a mutant immunoglobulin heavy chain (IgHV). Here we present a rare case of c-HCL with neither V600 BRAF mutation nor the aforementioned IgHV variant successfully treated with cladribine and review the current literature on its use in women of childbearing age/pregnancy.
Source: Leukemia Research Reports - Category: Hematology Source Type: research