The mechanically activated p38/MMP-2 signaling pathway promotes bone marrow mesenchymal stem cell migration in rats

Biomechanical stimuli are critical factors in development and maintenance of the skeleton as well as the cell phenotype and function (Goodman& Aspenberg, 1993; Luu et al., 2009). Accumulated evidence suggest that the stem cell niche in bone marrow provides a significant pool of mesenchymal stem cells (MSCs) (Kfoury& Scadden, 2015; Mendez-Ferrer et al., 2010). The biology of bone marrow mesenchymal stem cells (BMMSCs) is inevitably affected by mechanical strain loaded on the bone, particularly in the treatment of distraction osteogenesis (DO) and orthodontics, which make use of static strain for bone regeneration.

Source: Archives of Oral Biology - January 22, 2017 Category: Dentistry Authors: Zihui Yang, Baolei Wu, Sen Jia, Yinghua Zhao, Rui Hou, Xiaochang Liu, Xinge Wang, Litong Chen, Xinjie Yang, Delin Lei, Lei Wang Source Type: research