PAR2-mediated upregulation of BDNF contributes to central sensitization in bone cancer pain

Conclusion:
The present study demonstrated that activation of PAR2 triggered NF-kappaB signaling and significantly upregulated the BDNF function, which critically contributed to the enhancement of glutamatergic transmission in spinal dorsal horn and thermal and mechanical hypersensitivity in the rats with bone cancer. This indicated that PAR2 - NF-kappaB signaling might become a novel target for the treatment of pain in patients with bone cancer.

Source: Molecular Pain - May 5, 2014 Category: Molecular Biology Authors: Yanju BaoWei HouRui LiuYebo GaoXiangying KongLiping YangZhan ShiWeidong LiHonggang ZhengShulong JiangConghuang LiYinggang QinBaojin Hua Source Type: research