Relationship between vitamin D status and psychopathology in patients with first-episode schizophrenia: a cross-sectional study

Background: Deficient vitamin D is one of the implicated factors in the etiopathogenesis of schizophrenia and other mental disorders. However, there are scarce reports as regards its prevalence or associated problems among those with first-episode schizophrenia. Objective: The aim of this study was to assess 25-hydroxyvitamin D [25(OH)D] serum concentrations in first-episode schizophrenia male patients as compared with healthy controls and to determine whether a correlation exists between serum levels of 25(OH)D and disease activity. Methods: We enrolled 50 male patients with first-episode schizophrenia and compared them with 50 controls with no major psychopathology. The Positive and Negative Syndrome Scale for schizophrenia and the Montgomery–Asberg Depression Rating Scale for depression were administered on the same day. The blood samples were drawn and plasma 25(OH)D level was measured using immunoassay. Results: Lower serum 25(OH)D concentrations were detected among patients with first-episode schizophrenia (24.8±11.21 ng/ml) compared with controls (67.3±22.91 ng/ml, P10 weeks) and prominent negative and more severe depressive symptoms. Our finding may raise the suggestion that further treatment with add-on vitamin D supplements and diets that are rich in vitamin D may be beneficial.
Source: Middle East Current Psychiatry - Category: Psychiatry Tags: Original articles Source Type: research