Octopamine enhances oxidative stress resistance through the fasting ‐responsive transcription factor DAF‐16/FOXO in C. elegans

In this study, we found that OA administration enhanced organismal resistance to oxidative stress. This enhanced resistance was suppressed by a mutation of the OA receptors, SER‐3 and SER‐6. Moreover, we found that OA administration promoted the nuclear translocation of DAF‐16, the key transcription factor in fasting responses, and that the OA‐induced enhancement of stress resistance required DAF‐16. Altogether, our results suggest that OA signaling, which is triggered by the absence of food, shifts the organismal state to a more protective one to prepare for environmental stresses. In this study, we found that OA administration enhanced organismal resistance to oxidative stress. This enhanced resistance was suppressed by a mutation of the OA receptors, SER‐3 and SER‐6. Moreover, we found that OA administration promoted the nuclear translocation of DAF‐16, the key transcription factor in fasting responses, and that the OA‐induced enhancement of stress resistance required DAF‐16. Altogether, our results suggest that OA signaling, which is triggered by the absence of food, shifts the organismal state to a more protective one to prepare for environmental stresses.
Source: Genes to Cells - Category: Genetics & Stem Cells Authors: Tags: Original Article Source Type: research