Selective neuronal vulnerability in Parkinson disease

Nature Reviews Neuroscience 18, 101 (2017). doi:10.1038/nrn.2016.178 Authors: D. James Surmeier, José A. Obeso & Glenda M. Halliday Intracellular α-synuclein (α-syn)-rich protein aggregates called Lewy pathology (LP) and neuronal death are commonly found in the brains of patients with clinical Parkinson disease (cPD). It is widely believed that LP appears early in the disease and spreads in synaptically coupled brain networks, driving neuronal
Source: Nature Reviews Neuroscience - Category: Neuroscience Authors: Tags: Review Source Type: research