Selective neuronal vulnerability in Parkinson disease
Nature Reviews Neuroscience 18, 101 (2017).
doi:10.1038/nrn.2016.178
Authors: D. James Surmeier, José A. Obeso & Glenda M. Halliday
Intracellular α-synuclein (α-syn)-rich protein aggregates called Lewy pathology (LP) and neuronal death are commonly found in the brains of patients with clinical Parkinson disease (cPD). It is widely believed that LP appears early in the disease and spreads in synaptically coupled brain networks, driving neuronal
Source: Nature Reviews Neuroscience - Category: Neuroscience Authors: D. James Surmeier Jos é A. Obeso Glenda M. Halliday Tags: Review Source Type: research