Mycobacterium tuberculosis Rv1474c is a TetR-like transcriptional repressor that regulates aconitase, an essential enzyme and RNA-binding protein, in an iron-responsive manner

In this study, we identified Rv1474c as a TetR-like repressor of its operonic partner acn and carried out its biochemical and functional characterization. The binding motif for Rv1474c in the upstream region of acn (Rv1475c)-Rv1474c operon was verified by gel-shift assays.

Source: Tuberculosis - January 16, 2017 Category: Respiratory Medicine Authors: Kannan Balakrishnan, Krishnaveni Mohareer, Sharmistha Banerjee Source Type: research