Dihydromyricetin induces mitochondria-mediated apoptosis in HepG2 cells through down-regulation of the Akt/Bad pathway

This study was undertaken to elucidate the underlying molecular mechanism of action of DHM. In the study, DHM down-regulated Akt expression and its phosphorylation at Ser473, up-regulated the levels of mitochondrial pro-apoptotic proteins Bax and Bad, and inhibited the phosphorylation of Bad at Ser136 and Ser112. It also inhibited the expression of the anti-apoptotic protein Bcl-2 and enhanced the cleavage and activation of Caspase-3 as well as the degradation of its downstream target PARP.

Source: Nutrition Research - January 16, 2017 Category: Nutrition Authors: Zhuangwei Zhang, Huiqin Zhang, Shiyong Chen, Yan Xu, Anjun Yao, Qi Liao, Liyuan Han, Zuquan Zou, Xiaohong Zhang Source Type: research