Shape and geometry control of the Drosophila tracheal tubule

For efficient respiration, tubular airways must be constructed with an optimal diameter and length for the dimensions of the body. In Drosophila, the growth of embryonic tracheal tubules proceeds in two dimensions, by axial elongation and diameter expansion. The growth forces in each dimension are controlled by distinct genetic programs and cellular mechanisms. Recent studies reveal that the apical cortex and the apical extracellular matrix filling the luminal space are essential for the generation, balancing, and equilibrium of these growth forces. We here discuss the mechanical properties and architecture of the apical cortex and extracellular matrix, and their crucial roles in the tissue‐level coordination of tubule shape and geometry.

This review summarizes recent advances in tube shape and geometry control of the Drosophila tracheal system, with special emphasis on the role of apical extracellular matrix in tissue‐level coordination of mechanical activities of individual tracheal cells.

Source: Development, Growth and Differentiation - November 30, 2016 Category: Research Authors: Shigeo Hayashi, Bo Dong Tags: Review Article Source Type: research