The loss-of-function mutations and down-regulated expression of ASB3 gene promote the growth and metastasis of colorectal cancer cells.

CONCLUSION: ASB3 dysfunction resulted from gene mutations or down-regulated expression frequently exists in CRC and likely plays a key role in the pathogenesis and progression of CRC. PMID: 28088228 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/28088228?dopt=Abstract

Source: Chinese Journal of Cancer - January 17, 2017 Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research