The Importance of Breast Cancer Resistance Protein to the Kidneys Excretory Function and Chemotherapeutic Resistance

The relevance of membrane transporters gained momentum in recent years and it is now widely recognized that transporters are key players in drug disposition and chemoresistance. As such, the kidneys harbor a variety of drug transporters and are one of the main routes for xenobiotic excretion. The breast cancer resistance protein (BCRP/ABCG2) is widely accepted as a key mediator of anticancer drug resistance and is a prominent renal drug transporter. Here, we review the role of BCRP in both processes and present a multitude of variables that can influence its activity.
Source: Drug Resistance Updates - Category: Drugs & Pharmacology Authors: Tags: Invited review Source Type: research