Thirty Years of Evidence on the Efficacy of Drug Treatments for Chronic Heart Failure With Reduced Ejection Fraction: A Network Meta-Analysis [Original Articles]

Conclusions—
The network meta-analysis showed that treatment with ACEI, ARB, BB, MRA, and ARNI and their combinations were better than the treatment with placebo in reducing all-cause mortality, with the exception of ARB monotherapy and ARB plus ACEI. The combination of ARNI+BB+MRA resulted in the greatest mortality reduction.

Source: Circulation: Heart Failure - January 12, 2017 Category: Cardiology Authors: Burnett, H., Earley, A., Voors, A. A., Senni, M., McMurray, J. J. V., Deschaseaux, C., Cope, S. Tags: Heart Failure, Treatment, Meta Analysis, Mortality/Survival Original Articles Source Type: research