Neurodevelopmental Perspectives on Wnt Signaling in Psychiatry

This article reviews neurodevelopmental and postneurodevelopmental functions of Wnt signaling, highlighting mechanisms, whereby its disruption might contribute to psychiatric illness, and then reviews the most reliable recent genetic evidence supporting that mutations in Wnt pathway genes contribute to psychiatric illness. We are proponents of the notion that studies in animal and hiPSC models informed by the human genetic data combined with the deep knowledge base and tool kits generated over the last several decades of basic neurodevelopmental research will yield near-term tangible advances in neuropsychiatry.Mol Neuropsychiatry 2016;2:219-246
Source: Molecular Neuropsychiatry - Category: Neuroscience Source Type: research