Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin {alpha}v{beta}3/FAK/AKT Pathway Suppression [Original Articles]

Conclusions—
Osteoprotegerin facilitates PAH pathogenesis by regulating pulmonary arterial smooth muscle cell proliferation, suggesting that it may be a potential biomarker and therapeutic target in this disease.

Source: Circulation: Cardiovascular Genetics - January 10, 2017 Category: Cardiology Authors: Jia, D., Zhu, Q., Liu, H., Zuo, C., He, Y., Chen, G., Lu, A. Tags: Pulmonary Biology, Cell Signaling/Signal Transduction, Pulmonary Hypertension Original Articles Source Type: research