Peptide fibrils as monomer storage of the covalent HIV ‐1 integrase inhibitor

We report the inherent fibrillization of N‐terminal succinimide‐modified lens epithelium‐derived growth factor (361–370) peptide as an additional factor for covalent inhibition of HIV‐1 integrase. The fibrillization facilitates inhibition, which increases the local concentration at the target protein. This inhibitor is stored as fibrils that serve as a stock for the active inhibitory monomers. The monomer peptide serves both specific recognition sequence and the binding moiety. This approach can be a promising new strategy for developing therapeutic agents.

Source: Journal of Peptide Science - October 31, 2016 Category: Biochemistry Authors: Koushik Chandra, Priyadip Das, Norman Metanis, Assaf Friedler, Meital Reches Tags: Special Issue Article Source Type: research