Antioxidant treatment attenuates lactate production in diabetic nephropathy

In conclusion, this study demonstrates that diabetes-induced pseudohypoxia, as indicated by an increased lactate-to-pyruvate ratio, is significantly attenuated by antioxidant treatment. This demonstrates a pivotal role of oxidative stress in renal metabolic alterations occurring in early diabetes.

Source: AJP: Renal Physiology - January 8, 2017 Category: Urology & Nephrology Authors: Laustsen, C., Nielsen, P. M., Norlinger, T. S., Qi, H., Pedersen, U. K., Bertelsen, L. B., Ostergaard, J. A., Flyvbjerg, A., Ardenkjaer-Larsen, J. H., Palm, F., Stodkilde-Jorgensen, H. Tags: ARTICLES Source Type: research