Inverse Correlation Between the Metastasis Suppressor RKIP and the Metastasis Inducer YY1: Contrasting Roles in the Regulation of Chemo/Immuno-Resistance in Cancer

Several gene products have been postulated to mediate inherent and/or acquired anticancer drug resistance and tumor metastasis. Among these, the metastasis suppressor and chemo-immuno-sensitizing gene product, Raf Kinase Inhibitor Protein (RKIP), is poorly expressed in many cancers. In contrast, the metastasis inducer and chemo-immuno-resistant factor Yin Yang 1 (YY1) is overexpressed in many cancers. This inverse relationship between RKIP and YY1 expression suggests that these two gene products may be regulated via cross-talks of molecular signaling pathways, culminating in the expression of different phenotypes based on their targets.

Source: Drug Resistance Updates - January 8, 2017 Category: Drugs & Pharmacology Authors: Stephanie Wottrich, Samantha Kaufhold, Emmanuel Chrysos, Odysseas Zoras, Stavroula Baritaki, Benjamin Bonavida Source Type: research