Using discrete multi-physics for detailed exploration of hydrodynamics in an in vitro colon system

We developed a mathematical model that describes the motion of viscous fluids in the partially-filled colon caused by the periodic contractions of flexible walls (peristalsis). In-vitro data are used to validate the model. The model is then used to identify two fundamental mechanisms of mass transport: the surfing mode and the pouring mode. The first mechanism is faster, but only involves the surface of the liquid. The second mechanism causes deeper mixing, and appears to be the main transport mechanism.
Source: Computers in Biology and Medicine - Category: Bioinformatics Authors: Source Type: research