Aberrant spontaneous neural activity and correlation with evoked-brain potentials in first-episode, treatment-na ïve patients with deficit and non-deficit schizophrenia

Functional magnetic resonance imaging (fMRI) has been used extensively to understand the neuropathology of schizophrenia because of its high spatial resolution and non-invasiveness. In particular, resting-state fMRI, in which measurements are taken during rest, has been used to measure intrinsic (spontaneous) brain activity that does not depend on specific tasks. Such activity is typically measured in terms of the amplitude of low-frequency fluctuation (ALFF) (0.01 –0.08Hz) of the blood oxygenation level-dependent (BOLD) signal (He et al., 2013).

Source: Psychiatry Research: Neuroimaging - January 4, 2017 Category: Psychiatry Authors: Zhe Li, Wei Lei, Wei Deng, Zhong Zheng, Mingli Li, Xiaohong Ma, Qiang Wang, Chaohua Huang, Na Li, David A. Collier, Qiyong Gong, Tao Li Source Type: research