The role of splenectomy in autoimmune hematological disorders: Outdated or still worth considering?

We discuss the role of splenectomy in the autoimmune hematological disorders immune thrombocytopenia (ITP), autoimmune hemolytic anemia (AIHA) and thrombotic thrombocytopenic purpura (TTP). Management of these disorders has dramatically changed the past decade as increasing knowledge of the immunopathogenesis has led to the introduction of new therapies. Until 10years ago, splenectomy was the established second-line treatment for ITP, considered when corticosteroids failed to induce a sustained response.

Source: Blood Reviews - January 3, 2017 Category: Hematology Authors: Judith Sys, Drew Provan, Alexander Schauwvlieghe, Steven Vanderschueren, Daan Dierickx Tags: Review Source Type: research