TRAIL signaling is proinflammatory and proviral in a murine model of rhinovirus 1B infection

In conclusion, TRAIL promotes RV-induced AHR, inflammation and RV1B replication, implicating this molecule and its downstream signaling pathways as a possible target for the amelioration of RV1B-induced allergic and nonallergic lung inflammation and AHR.

Source: AJP: Lung Cellular and Molecular Physiology - December 31, 2016 Category: Respiratory Medicine Authors: Girkin, J. L., Hatchwell, L. M., Collison, A. M., Starkey, M. R., Hansbro, P. M., Yagita, H., Foster, P. S., Mattes, J. Tags: RESEARCH ARTICLE Source Type: research