Regulation and function of bone morphogenetic protein signaling in colonic injury and inflammation

In this study we report a series of novel observations that underscore the importance of bone morphogenetic protein (BMP) signaling in the regulation of colonic homeostasis during the development of injury and inflammation. In particular, we present evidence that BMP signaling mitigates the response of the colonic epithelium to injury and inflammation and that cytokines, such as TNF-α and IL-1β, inhibit the expression of BMP-4.

Source: AJP: Gastrointestinal and Liver Physiology - December 31, 2016 Category: Gastroenterology Authors: Ji, T., Takabayashi, H., Mao, M., Han, X., Xue, X., Brazil, J. C., Eaton, K. A., Shah, Y. M., Todisco, A. Tags: RESEARCH ARTICLE Source Type: research