TNF-alpha stimulation increases dental pulp stem cell migration in vitro through integrin alpha-6 subunit upregulation

Dental pulp stem cell migration is one of the critical events in execution of an inflammatory response in afflicted pulpal tissues. hDPSCs have the propensity to regenerate dental tissues in vivo (Shi et al., 2005). Presence of stem cells within the microenvironment of dental pulp (Gronthos, Mankani, Brahim, Robey,& Shi, 2000) demands a clear knowledge of the mechanisms by which they are recruited after damage occurs in dental tissues. After extensive research, stem cells of dental origin are now considered an effective tool in establishing an instant repair response manifested through homing of stem cells and subsequent chemotaxis, adhesion, proliferation, differentiation and regeneration (Cooper et al., 2010).
Source: Archives of Oral Biology - Category: Dentistry Authors: Tags: Original research article Source Type: research