Expression of matrix metalloproteinases-2, -9 and reversion-inducing cysteine-rich protein with Kazal motifs in gingiva in periodontal health and disease

Periodontitis, representing the second most prevalent oral diseases, is a biofilm-induced chronic destructive periodontal inflammation that eventually leads to the loosening and loss of teeth. Generated from the imbalance between the subgingival microorganisms and the over-aggressive host defense (Sanz, van Winkelhoff,& Working Group 1 of Seventh European Workshop on Periodontology, 2011), the pathological process of periodontitis is characterized by the destruction of tooth-supporting structures that results from the degradation and remodelling of extracellular matrix(ECM), which is principally mediated by the orchestrated stimulation of a large group of proteolytic host enzymes (Reynolds and Meikle, 1997).

Source: Archives of Oral Biology - December 25, 2016 Category: Dentistry Authors: Nian Liu, Yingguang Cao, Guangxun Zhu Source Type: research