Targeted P2X7R shRNA Delivery Attenuates Sympathetic Nerve Sprouting and Ameliorates Cardiac Dysfunction in Rats with Myocardial Infarction

ConclusionsThe administration of P2X7R RNAi during the acute inflammatory response phase prevented the process of sympathetic hyperinnervation after MI, which was associated in part with inhibiting the Akt and ERK1/2 pathways and NF‐κB activation.This article is protected by copyright. All rights reserved.

Source: Cardiovascular Therapeutics - December 30, 2016 Category: Cardiology Authors: Hongmei Gao, Jie Yin, Yugen Shi, Hesheng Hu, Xiaolu Li, Mei Xue, Wenjuan Cheng, Ye Wang, Xinran Li, Yongkang Li, Yu Wang, Suhua Yan Tags: Original Research Article Source Type: research