Clinical studies of ex vivo expansion to accelerate engraftment after umbilical cord blood transplantation: a systematic review

Cell dose limits greater use of umbilical cord blood (UCB) in hematopoietic cell transplantation (HCT). The clinical benefits of ex vivo expansion needs clarity to understand its potential impact. A systematic search of studies addressing UCB ex vivo expansion was conducted. 15 clinical studies (349 transplanted patients) and 13 registered trials were identified. The co-infusion of an expanded unit and a second unmanipulated unit (8 studies), the fractional expansion of a 12 –60% of a single unit (5 studies) and the infusion of a single expanded unit (2 studies) were reported.
Source: Transfusion Medicine Reviews - Category: Hematology Authors: Tags: Clinical Trial Source Type: research