Synthesis of Novel Pyrazolines, Their Boron –Fluorine Complexes, and Investigation of Antibacterial, Antioxidant, and Enzyme Inhibition Activities

New 3,5‐disubstituted‐2‐pyrazoline derivatives (4–6), their boron‐fluorine complexes (boron (3‐(2′‐aminophenyl),5‐(2′‐/3′‐/4′‐pyridyl)pyrazoline, BOAPPY) (7–9) and boron 1,2′‐diazaflavone complex (BODAF) (11) were synthesized starting from azachalcones (1–3) to diazaflavone (10), respectively. Biological evaluation of compounds 4–9 and 11 showed remarkable antioxidant, antibacterial, and acetylcholinesterase and tyrosinase enzyme inhibition activities. All newly synthesized compounds 4–9 and 11 showed respectable antibacterial effect with minimum inhibitory concentrations in the range of 4.7–150 μg/mL. New 3,5‐disubstituted‐2‐pyrazoline derivatives (4–6), their boron‐fluorine complexes (BOAPPY) (7–9) and boron 1,2′‐diazaflavone complex (BODAF) (11) were synthesized starting from azachalcones to diazaflavone, respectively. Compounds 4–9 and 11 showed remarkable antioxidant, antibacterial, acetylcholinesterase‐inhibitory, and tyrosinase‐inhibitory activities, as well as good antibacterial effects.
Source: Archiv der Pharmazie - Category: Drugs & Pharmacology Authors: Tags: Full Paper Source Type: research