Bidimensional unconstrained optimization approach to EMD: an algorithm revealing skin perfusion alterations in pseudoxanthoma elasticum patients

Pseudoxanthoma elasticum (PXE) is a heritable systemic metabolic disorder that leads to ectopic calcification of soft connective tissue [2,7,26]. Alterations in the ABCC6 gene have been associated with the disease  (see, e.g., [3]). The organs that are primarily affected by PXE are the skin and the eyes [17]. Cutaneous lesions in PXE are asymptomatic yellow-white papules. These papules usually have a diameter of 2 to 5 mm and are “dome-shaped”. The skin thus resembles an orange peel (peau d’orange), s ee Fig. 1.

Source: Computer Methods and Programs in Biomedicine - December 27, 2016 Category: Bioinformatics Authors: Anne Humeau-Heurtier, Marcelo A. Colominas, Gast ón Schlotthauer, Maxime Etienne, Ludovic Martin, Pierre Abraham Source Type: research