Copy number alterations unmasked as enhancer hijackers
Nature Genetics 49, 5 (2017).
doi:10.1038/ng.3754
Authors: Rameen Beroukhim, Xiaoyang Zhang & Matthew Meyerson
Our understanding of how DNA copy number changes contribute to disease, including cancer, has to a large degree been focused on the changes in gene dosage that they generate and has neglected the effects of the DNA rearrangements that lead to their formation. A new study reports an innovative analytical framework for copy number alterations that are oncogenic primarily owing to the genomic rearrangements that underlie them.
Source: Nature Genetics - Category: Genetics & Stem Cells Authors: Rameen Beroukhim Xiaoyang Zhang Matthew Meyerson Tags: News and Views Source Type: research