Meningeal SWI/SNF related, matrix ‐associated, actin‐dependent regulator of chromatin, subfamily B member 1 (SMARCB1)‐deficient tumours: an emerging group of meningeal tumours

ConclusionsThe phenotype and genotype of these two cases did not fit diagnostically with entities already known to be SMARCB1‐deficient tumours. As both tumours shared common features, they are regarded as belonging to an emerging group of primary meningeal SMARCB1‐deficient tumours, not described to date. To facilitate the identification and characterization of these tumours, we recommend SMARCB1 immunohistochemistry for primary meningeal tumours which are difficult to classify, especially if immunopositive for EMA and CD34.

Source: Neuropathology and Applied Neurobiology - December 27, 2016 Category: Neurology Authors: B. Dadone, D. Fontaine, L. Mondot, G. Cristofari, A. Jouvet, C. Godfraind, P. Varlet, D. Ranch ère‐Vince, J.‐M. Coindre, L. Gastaud, C. Baudoin, A.‐C. Peyron, A. Thyss, M. Coutts, J.‐F. Michiels, F. Pedeutour, F. Burel‐Vandenbos, Tags: Original Article Source Type: research