Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections

Nature Neuroscience 20, 16 (2017). doi:10.1038/nn.4447 Authors: Daniel Justus, Dennis Dalügge, Stefanie Bothe, Falko Fuhrmann, Christian Hannes, Hiroshi Kaneko, Detlef Friedrichs, Liudmila Sosulina, Inna Schwarz, David Anthony Elliott, Susanne Schoch, Frank Bradke, Martin Karl Schwarz & Stefan Remy The medial septum and diagonal band of Broca (MSDB) send glutamatergic axons to medial entorhinal cortex (MEC). We found that this pathway provides speed-correlated input to several MEC cell-types in layer 2/3. The speed signal is integrated most effectively by pyramidal cells but also excites stellate cells and interneurons. Thus, the MSDB conveys speed information that can be used by MEC neurons for spatial representation of self-location.
Source: Nature Neuroscience - Category: Neuroscience Authors: Tags: Brief Communication Source Type: research