Development of antibacterial conjugates using sulfamethoxazole with monocyclic terpenes: a systematic medicinal chemistry based computational approach

The Gram-positive (GP) bacterium, methicillin resistant Staphylococcus aureus (MRSA) causes commonplace infection at hospital and community sectors, with simultaneous aggrandizement of resistance to several antibiotics [1, 2, 3, 4], resulting in additional morbidity and unexpected mortality, through bacteremia. Consequently, it has become now a major public health concern, because very few antibiotics remain effective. Escherichia coli is another shockingly repelling, commensal-turned-pathogen, suffused in communities with several versatile strains causing a range of enteric diseases [5], and urinary tract infection (UTI) normally in females, particularly in the elderly with concomitant diarrhea even [6, 7].
Source: Computer Methods and Programs in Biomedicine - Category: Bioinformatics Authors: Tags: Original article Source Type: research