A deletion hampering appropriate typing of Mycobacterium africanum

Molecular epidemiology analysis of tuberculosis transmission is based mostly on the application of MIRU-VNTR. In certain isolates a complete 24-loci genotype is not obtained and these incompletely genotyped isolates can not be used in the definition of clusters. In a population-based molecular epidemiology study performed in Almer ía, Southeast Spain, a context with a high proportion of immigrants, we found that an 88-bp deletion in isolates of Mycobacterium africanum Lineage 5 hampers MIRU-VNTR analysis.

Source: Tuberculosis - December 25, 2016 Category: Respiratory Medicine Authors: Estefan ía Abascal, Diana Maricela Herrera, Marta Herranz, Sheila Santantón, Miguel Martínez Lirola, Griselda Tudó, Juliá Gonzalez, Emilio Bouza, Laura Pérez-Lago, Darío García-de-Viedma Source Type: research