The analgesic effect of orexin-A in a murine model of chemotherapy-induced neuropathic pain
Orexins are neuropeptides that are localized to neurons in the lateral and dorsal hypothalamus but its receptors are distributed to many different regions of the central nervous system. Orexins are implicated in a variety of physiological functions including sleep regulation, energy homeostats, and stress reactions. Furthermore, orexins administered exogenously have been shown to have analgesic effects in animal models. A type of intractable pain in patients is pain due to chemotherapy-induced peripheral neuropathy (CIPN).
Source: Neuropeptides - Category: Neuroscience Authors: Satoshi Toyama, Naohito Shimoyama, Megumi Shimoyama Tags: News Source Type: research
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