Toxicological studies of caesalpinia sappanwood derived dye in wister albino rats

Publication date: Available online 23 December 2016 Source:Food Science and Human Wellness Author(s): G. Athinarayanana, A.J.A. Ranjitsingh, A. Usha Raja Nanthini, C. Padmalatha Natural dyes taken from the barks of the tree Caesalpinia sappanhas been used in many consumer products. Hence it is imperative to test the toxicity of this dye. In the present study an investigation was conducted to find out the toxic effect of aqueous extract of the dye C.sappanin test animal wister albino rats. Acute oral toxicity showed no clinical signs of toxicity and no mortality even at a dose level of 100–2000mg/kg in 14days observation period. When a dose level above 2500mg/kg given for 28 days, no death was noticed up to the dose level 5000mg/kg body weight. The weight of the tested rats did not get significant reduction, when compared with the control group. The organ − body weight ratio of Kidney, Liver and Abdomen did not change when compared to the control group in the observation period. The less toxicity of the dyes of C.sappan Graphical abstract
Source: Food Science and Human Wellness - Category: Food Science Source Type: research