High levels of iron supplementation prevents neural tube defects in the Fpn1ffe mouse model

ConclusionOur results demonstrate that iron supplementation can prevent NTDs and forebrain truncations in the Fpn1ffe model. Surprisingly, high levels of iron supplementation and iron overload can cause folate deficiency. If iron is essential for neural tube closure, it is possible that iron deficiency might contribute to NTDs. Birth Defects Research (Part A), 2016. © 2016 The Authors Birth Defects Research Part A: Clinical and Molecular Teratology Published by Wiley Periodicals, Inc.

Source: Birth Defects Research Part A: Clinical and Molecular Teratology - December 22, 2016 Category: Perinatology & Neonatology Authors: Bethany A. Stokes, Julia A. Sabatino, Irene E. Zohn Tags: Original Research Article Source Type: research