DNA Methylation Analysis in Malignant Pheochromocytoma and Paraganglioma

Conclusions Here, we report two noteworthy genes, ACSBG1 and MAST1; the aberrant promoter methylation/demethylation of these genes might be involved in their silencing/expression in malignant PCC/PGL. Further investigations are necessary to determine the role of ACSBG1 and/or MAST1 expression in malignant transformation and to establish pathological markers that can evaluate the malignant potential of PCC/PGL.
Source: Journal of Clinical and Translational Endocrinology - Category: Endocrinology Source Type: research