Impairment of dynamic thiol –disulphide homeostasis in patients with idiopathic Parkinson’s disease and its relationship with clinical stage of disease

Parkinson ’s disease (PD), which is clinically characterised by rigidity, resting tremor, bradykinesia and postural instability, is the most common neurodegenerative disorder after Alzheimer's disease [1]. It is pathologically characterised by progressive degeneration of dopaminergic neurons in the substant ia nigra (SN) [2]. Although the reasons of dopaminergic neurodegeneration remain unknown it is believed that multifactorial causes, such as genetic and environmental triggers, play a role in the pathogenesis of the disease.

Source: Clinical Neurology and Neurosurgery - December 21, 2016 Category: Neurosurgery Authors: Gonul Vural, Sadiye Gumusyayla, Hesna Bektas, Orhan Deniz, Murat Al ışık, Ozcan Erel Source Type: research