Transient Local Bone Remodeling Effects of rhBMP-2 in an Ovine Interbody Spine Fusion Model

Conclusions:
In the ovine end-plate-sparing interbody fusion model, rhBMP-2 dose-dependent osteoclastic resorption is a transient phenomenon that peaks at 4 weeks postoperatively.

Clinical Relevance:
Using the U.S. Food and Drug Administration (FDA)-approved rhBMP-2 concentration and matching the volume of rhBMP-2/ACS with the volume of desired bone formation within the interbody construct may limit the occurrence of transient bone resorption.

Source: JBJS - December 20, 2016 Category: Orthopaedics Authors: Bae, H. W., Patel, V. V., Sardar, Z. M., Badura, J. M., Pradhan, B. B., Seim, H. B., Turner, A. S., Toth, J. M. Tags: Basic Science Scientific Articles Source Type: research