The absorption kinetics of ketoconazole plays a major role in explaining the reported variability in the level of interaction with midazolam: exploring the interplay between formulation and inhibition of gut wall and liver metabolism by using different doses of inhibitor and staggering the dose of substrate

This study also emphasises a need to account for inter‐individual variability in the gut wall and systemic exposure of inhibitors with physicochemical properties similar to KTZ, in particular in their rate of oral absorption and when using different pharmaceutical formulations, in designing and evaluating the extent of drug – drug interactions.
Source: Biopharmaceutics and Drug Disposition - Category: Drugs & Pharmacology Authors: Tags: Original Paper Source Type: research