The angiotensin II type 1 receptor blocker losartan attenuates bioprosthetic valve leaflet calcification in a rabbit intravascular implant model [EXPERIMENTAL]

CONCLUSIONS Our results indicate that losartan significantly attenuates postimplant degenerative calcification of a bovine pericardial bioprosthesis in a rabbit intravascular implant model. Further studies are required to assess the effects of ARBs on BHV tissue in orthotopic implantations using a large animal model.

http://ejcts.oxfordjournals.org/cgi/content/short/50/6/1045?rss=1

Source: European Journal of Cardio-Thoracic Surgery - December 19, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Shin, H. J., Kim, D.-H., Park, H. K., Park, Y. H. Tags: Basic research vascular EXPERIMENTAL Source Type: research