Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Thiosulfate in Human Blood and Urine as an Indicator of Hydrogen Sulfide Poisoning

Hydrogen sulfide poisoning (HSP) occurs due to industrial poisoning incidents at chemical factories, human excreta, and sludge treatment plants as well as from exposure to volcano-released gases and oral ingestion of sulfur-containing pesticides or bath additives. In addition, recent HSP incidents involving hydrogen sulfide gas released from mixing sulfur-containing products with toilet cleaner have also been reported. Hitherto, confirmation of HSP has been performed by analysis of sulfides and their metabolites in body fluids and tissues of the deceased [1 –5].

Source: Legal Medicine - December 16, 2016 Category: Forensic Medicine Authors: Chikatoshi Maseda, Akira Hayakawa, Katsuhiro Okuda, Masaru Asari, Hiroki Tanaka, Hiromi Yamada, Shigeki Jin, Kie Horioka, Kotaro Matoba, Hiroshi Shiono, Kazuo Matsubara, Keiko Shimizu Source Type: research