Fitting local repolarization parameters in cardiac reaction-diffusion models in the presence of electrotonic coupling

Background: Repolarization gradients contribute to arrhythmogenicity. In reaction –diffusion models of cardiac tissue, heterogeneities in action potential duration (APD) can be created by locally modifying an intrinsic membrane kinetics parameter. Electrotonic coupling, however, acts as a confounding factor that modulates APD dispersion.Method: We developed an algorithm based o n a quasi-Newton method that iteratively adjusts the spatial distribution of a membrane parameter to reproduce a pre-defined target APD map in a coupled tissue.
Source: Computers in Biology and Medicine - Category: Bioinformatics Authors: Source Type: research