Analyses of Differentially Expressed Genes After Exposure To Acute Stress, Acute Ethanol, Or A Combination Of Both In Mice

Alcohol abuse is a complex disorder, which is confounded by other factors, including stress. In the present study, we examined gene expression in the hippocampus of BXD recombinant inbred mice after exposure to ethanol (NOE), stress (RSS), and the combination of both (RSE). Mice were given an intraperitoneal (i.p.) injection of 1.8 g/kg ethanol or saline, and subsets of both groups were exposed to acute restraint stress for 15 min or controls. Gene expression in the hippocampus was examined using microarray analysis.

Source: Alcohol - December 15, 2016 Category: Addiction Authors: Jessica A. Baker, Jingxin Li, Diana Zhou, Ming Yang, Melloni N. Cook, Byron C. Jones, Megan K. Mulligan, Kristin M. Hamre, Lu Lu Source Type: research