Human eIF3b and eIF3a serve as the nucleation core for the assembly of eIF3 into two interconnected modules: the yeast-like core and the octamer

This study, outlining the mechanism of eIF3 assembly and illustrating how imbalanced expression of eIF3 subunits impacts the factor's overall expression profile, thus provides a comprehensive guide to the human eIF3 complex and to the relationship between eIF3 misregulation and cancer.

Source: Nucleic Acids Research - December 14, 2016 Category: Research Authors: Wagner, S., Herrmannova, A., Sikrova, D., Valasek, L. S. Tags: Molecular Biology Source Type: research